├── data.json
├── index.html
├── sketch.js
└── yt-data.json


/data.json:
--------------------------------------------------------------------------------
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 859 |       "value": 2
 860 |     },
 861 |     {
 862 |       "source": "Cyclic and Macrocyclic Peptides as Chemical Tools To Recognise Protein Surfaces and Probe Protein-Protein Interactions.",
 863 |       "target": "137-231-469-269-151",
 864 |       "value": 2
 865 |     },
 866 |     {
 867 |       "source": "8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.",
 868 |       "target": "031-072-815-607-16X",
 869 |       "value": 2
 870 |     },
 871 |     {
 872 |       "source": "8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.",
 873 |       "target": "105-312-070-982-098",
 874 |       "value": 2
 875 |     },
 876 |     {
 877 |       "source": "8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.",
 878 |       "target": "018-515-082-074-296",
 879 |       "value": 2
 880 |     },
 881 |     {
 882 |       "source": "Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2)",
 883 |       "target": "027-228-373-793-594",
 884 |       "value": 2
 885 |     },
 886 |     {
 887 |       "source": "SIK2 regulates CRTCs, HDAC4 and glucose uptake in adipocytes",
 888 |       "target": "016-712-604-622-721",
 889 |       "value": 2
 890 |     },
 891 |     {
 892 |       "source": "Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2-Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases",
 893 |       "target": "086-316-087-480-933",
 894 |       "value": 2
 895 |     },
 896 |     {
 897 |       "source": "Nrf2 regulates ROS production by mitochondria and NADPH oxidase.",
 898 |       "target": "118-309-833-112-117",
 899 |       "value": 2
 900 |     },
 901 |     {
 902 |       "source": "The clinically approved drugs dasatinib and bosutinib induce anti-inflammatory macrophages by inhibiting the salt-inducible kinases",
 903 |       "target": "134-672-819-080-83X",
 904 |       "value": 2
 905 |     },
 906 |     {
 907 |       "source": "New Monocyclic, Bicyclic, and Tricyclic Ethynylcyanodienones as Activators of the Keap1/Nrf2/ARE Pathway and Inhibitors of Inducible Nitric Oxide Synthase",
 908 |       "target": "036-789-224-520-054",
 909 |       "value": 2
 910 |     },
 911 |     {
 912 |       "source": "Palmitoylation of the Na/Ca exchanger cytoplasmic loop controls its inactivation and internalization during stress signaling",
 913 |       "target": "106-594-488-484-12X",
 914 |       "value": 2
 915 |     },
 916 |     {
 917 |       "source": "Molecular Cloning and Functional Characterization of Components of the Capsule Biosynthesis Complex of Neisseria meningitidis Serogroup A TOWARD IN VITRO VACCINE PRODUCTION",
 918 |       "target": "125-726-727-125-409",
 919 |       "value": 2
 920 |     },
 921 |     {
 922 |       "source": "A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes",
 923 |       "target": "161-487-188-181-03X",
 924 |       "value": 2
 925 |     },
 926 |     {
 927 |       "source": "A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes",
 928 |       "target": "076-538-237-089-675",
 929 |       "value": 2
 930 |     },
 931 |     {
 932 |       "source": "A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes",
 933 |       "target": "051-324-518-696-462",
 934 |       "value": 2
 935 |     },
 936 |     {
 937 |       "source": "A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes",
 938 |       "target": "198-017-973-913-570",
 939 |       "value": 2
 940 |     },
 941 |     {
 942 |       "source": "A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes",
 943 |       "target": "156-653-831-632-101",
 944 |       "value": 2
 945 |     },
 946 |     {
 947 |       "source": "A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes",
 948 |       "target": "178-739-712-688-618",
 949 |       "value": 2
 950 |     },
 951 |     {
 952 |       "source": "A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes",
 953 |       "target": "048-634-530-447-798",
 954 |       "value": 2
 955 |     },
 956 |     {
 957 |       "source": "An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation",
 958 |       "target": "131-486-498-702-07X",
 959 |       "value": 2
 960 |     },
 961 |     {
 962 |       "source": "An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation",
 963 |       "target": "010-031-167-075-106",
 964 |       "value": 2
 965 |     },
 966 |     {
 967 |       "source": "Crystallographic analysis of Neisseria meningitidis PorB extracellular loops potentially implicated in TLR2 recognition",
 968 |       "target": "119-453-428-180-987",
 969 |       "value": 2
 970 |     },
 971 |     {
 972 |       "source": "The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver",
 973 |       "target": "016-712-604-622-721",
 974 |       "value": 2
 975 |     },
 976 |     {
 977 |       "source": "Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase",
 978 |       "target": "153-595-914-216-97X",
 979 |       "value": 2
 980 |     },
 981 |     {
 982 |       "source": "Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase",
 983 |       "target": "148-353-591-913-750",
 984 |       "value": 2
 985 |     },
 986 |     {
 987 |       "source": "Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase",
 988 |       "target": "019-827-938-996-490",
 989 |       "value": 2
 990 |     },
 991 |     {
 992 |       "source": "3-(2-oxoethylidene)indolin-2-one derivatives activate Nrf2 and inhibit NF-κB: potential candidates for chemoprevention.",
 993 |       "target": "184-646-935-269-773",
 994 |       "value": 2
 995 |     },
 996 |     {
 997 |       "source": "3-(2-oxoethylidene)indolin-2-one derivatives activate Nrf2 and inhibit NF-κB: potential candidates for chemoprevention.",
 998 |       "target": "186-230-275-872-748",
 999 |       "value": 2
1000 |     },
1001 |     {
1002 |       "source": "3-(2-oxoethylidene)indolin-2-one derivatives activate Nrf2 and inhibit NF-κB: potential candidates for chemoprevention.",
1003 |       "target": "165-291-395-706-725",
1004 |       "value": 2
1005 |     },
1006 |     {
1007 |       "source": "3-(2-oxoethylidene)indolin-2-one derivatives activate Nrf2 and inhibit NF-κB: potential candidates for chemoprevention.",
1008 |       "target": "047-113-007-956-15X",
1009 |       "value": 2
1010 |     },
1011 |     {
1012 |       "source": "3-(2-oxoethylidene)indolin-2-one derivatives activate Nrf2 and inhibit NF-κB: potential candidates for chemoprevention.",
1013 |       "target": "089-019-916-582-397",
1014 |       "value": 2
1015 |     },
1016 |     {
1017 |       "source": "3-(2-oxoethylidene)indolin-2-one derivatives activate Nrf2 and inhibit NF-κB: potential candidates for chemoprevention.",
1018 |       "target": "136-000-598-663-919",
1019 |       "value": 2
1020 |     },
1021 |     {
1022 |       "source": "Carnosic acid stimulates glucose uptake in skeletal muscle cells via a PME-1/PP2A/PKB signalling axis",
1023 |       "target": "051-072-189-723-758",
1024 |       "value": 2
1025 |     },
1026 |     {
1027 |       "source": "Kv1.3 inhibitors have differential effects on glucose uptake and AMPK activity in skeletal muscle cell lines and mouse ex vivo skeletal muscle",
1028 |       "target": "040-766-915-457-886",
1029 |       "value": 2
1030 |     },
1031 |     {
1032 |       "source": "Kv1.3 inhibitors have differential effects on glucose uptake and AMPK activity in skeletal muscle cell lines and mouse ex vivo skeletal muscle",
1033 |       "target": "141-482-415-400-338",
1034 |       "value": 2
1035 |     },
1036 |     {
1037 |       "source": "Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation",
1038 |       "target": "149-129-599-518-595",
1039 |       "value": 2
1040 |     },
1041 |     {
1042 |       "source": "Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation",
1043 |       "target": "156-286-485-464-499",
1044 |       "value": 2
1045 |     },
1046 |     {
1047 |       "source": "Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65",
1048 |       "target": "001-353-214-346-040",
1049 |       "value": 2
1050 |     },
1051 |     {
1052 |       "source": "Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65",
1053 |       "target": "118-479-143-842-720",
1054 |       "value": 2
1055 |     },
1056 |     {
1057 |       "source": "Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65",
1058 |       "target": "007-641-959-106-118",
1059 |       "value": 2
1060 |     },
1061 |     {
1062 |       "source": "Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65",
1063 |       "target": "189-040-066-278-226",
1064 |       "value": 2
1065 |     },
1066 |     {
1067 |       "source": "Substrate recognition by the cell surface palmitoyl transferase DHHC5.",
1068 |       "target": "106-594-488-484-12X",
1069 |       "value": 2
1070 |     },
1071 |     {
1072 |       "source": "Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy",
1073 |       "target": "026-244-336-682-442",
1074 |       "value": 2
1075 |     },
1076 |     {
1077 |       "source": "Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities",
1078 |       "target": "074-937-457-594-345",
1079 |       "value": 2
1080 |     },
1081 |     {
1082 |       "source": "Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities",
1083 |       "target": "168-286-254-597-740",
1084 |       "value": 2
1085 |     },
1086 |     {
1087 |       "source": "The Nrf2 regulatory network provides an interface between redox and intermediary metabolism",
1088 |       "target": "109-916-358-959-05X",
1089 |       "value": 2
1090 |     },
1091 |     {
1092 |       "source": "Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases",
1093 |       "target": "002-458-268-309-533",
1094 |       "value": 2
1095 |     },
1096 |     {
1097 |       "source": "Synthesis of vitamin D3 analogues with A-ring modifications to directly measure vitamin D levels in biological samples",
1098 |       "target": "038-310-729-099-192",
1099 |       "value": 2
1100 |     },
1101 |     {
1102 |       "source": "Synthesis of vitamin D3 analogues with A-ring modifications to directly measure vitamin D levels in biological samples",
1103 |       "target": "179-033-965-606-598",
1104 |       "value": 2
1105 |     },
1106 |     {
1107 |       "source": "Synthesis of vitamin D3 analogues with A-ring modifications to directly measure vitamin D levels in biological samples",
1108 |       "target": "113-229-447-433-64X",
1109 |       "value": 2
1110 |     },
1111 |     {
1112 |       "source": "Synthesis of vitamin D3 analogues with A-ring modifications to directly measure vitamin D levels in biological samples",
1113 |       "target": "077-771-399-719-227",
1114 |       "value": 2
1115 |     },
1116 |     {
1117 |       "source": "Synthesis of vitamin D3 analogues with A-ring modifications to directly measure vitamin D levels in biological samples",
1118 |       "target": "183-966-651-664-305",
1119 |       "value": 2
1120 |     },
1121 |     {
1122 |       "source": "Synthesis of vitamin D3 analogues with A-ring modifications to directly measure vitamin D levels in biological samples",
1123 |       "target": "013-467-292-050-692",
1124 |       "value": 2
1125 |     },
1126 |     {
1127 |       "source": "Structure-activity relationship studies of pyrrolone antimalarial agents",
1128 |       "target": "079-314-054-163-947",
1129 |       "value": 2
1130 |     },
1131 |     {
1132 |       "source": "Structure-activity relationship studies of pyrrolone antimalarial agents",
1133 |       "target": "110-082-309-221-187",
1134 |       "value": 2
1135 |     },
1136 |     {
1137 |       "source": "The Concise Guide to Pharmacology 2013/14.: The Concise Guide to Pharmacology 2013/14: G Protein-Coupled Receptors",
1138 |       "target": "128-382-566-327-896",
1139 |       "value": 2
1140 |     },
1141 |     {
1142 |       "source": "The Concise Guide to Pharmacology 2013/14.: The Concise Guide to Pharmacology 2013/14: G Protein-Coupled Receptors",
1143 |       "target": "143-543-676-408-839",
1144 |       "value": 2
1145 |     },
1146 |     {
1147 |       "source": "Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors",
1148 |       "target": "005-743-260-244-802",
1149 |       "value": 2
1150 |     },
1151 |     {
1152 |       "source": "Metabolism of inflammation limited by AMPK and pseudo-starvation",
1153 |       "target": "026-638-223-054-804",
1154 |       "value": 2
1155 |     },
1156 |     {
1157 |       "source": "Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration",
1158 |       "target": "048-208-660-423-215",
1159 |       "value": 2
1160 |     },
1161 |     {
1162 |       "source": "The anti-inflammatory compound BAY 11-7082 is a potent inhibitor of Protein Tyrosine Phosphatases",
1163 |       "target": "159-658-602-048-982",
1164 |       "value": 2
1165 |     },
1166 |     {
1167 |       "source": "BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm",
1168 |       "target": "077-811-145-153-079",
1169 |       "value": 2
1170 |     },
1171 |     {
1172 |       "source": "BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm",
1173 |       "target": "170-781-236-728-970",
1174 |       "value": 2
1175 |     },
1176 |     {
1177 |       "source": "BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm",
1178 |       "target": "144-284-594-583-951",
1179 |       "value": 2
1180 |     },
1181 |     {
1182 |       "source": "Investigation of acyclic uridine amide and 5′-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase",
1183 |       "target": "139-409-891-293-77X",
1184 |       "value": 2
1185 |     },
1186 |     {
1187 |       "source": "Discovery and structure-activity relationships of pyrrolone antimalarials",
1188 |       "target": "110-082-309-221-187",
1189 |       "value": 2
1190 |     },
1191 |     {
1192 |       "source": "De Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding Fragments",
1193 |       "target": "081-017-751-048-013",
1194 |       "value": 2
1195 |     },
1196 |     {
1197 |       "source": "De Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding Fragments",
1198 |       "target": "114-963-910-586-828",
1199 |       "value": 2
1200 |     },
1201 |     {
1202 |       "source": "De Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding Fragments",
1203 |       "target": "162-513-842-046-362",
1204 |       "value": 2
1205 |     },
1206 |     {
1207 |       "source": "Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies",
1208 |       "target": "188-803-921-043-695",
1209 |       "value": 2
1210 |     },
1211 |     {
1212 |       "source": "From On-Target to Off-Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti-Trypanosoma brucei Drug Discovery Lead Molecules",
1213 |       "target": "191-147-881-232-285",
1214 |       "value": 2
1215 |     },
1216 |     {
1217 |       "source": "From On-Target to Off-Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti-Trypanosoma brucei Drug Discovery Lead Molecules",
1218 |       "target": "081-817-015-173-962",
1219 |       "value": 2
1220 |     },
1221 |     {
1222 |       "source": "HIF-independent role of prolyl hydroxylases in the cellular response to amino acids",
1223 |       "target": "106-530-060-683-82X",
1224 |       "value": 2
1225 |     },
1226 |     {
1227 |       "source": "HIF-independent role of prolyl hydroxylases in the cellular response to amino acids",
1228 |       "target": "133-935-409-400-672",
1229 |       "value": 2
1230 |     },
1231 |     {
1232 |       "source": "Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones",
1233 |       "target": "046-588-899-387-353",
1234 |       "value": 2
1235 |     },
1236 |     {
1237 |       "source": "Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones",
1238 |       "target": "051-324-518-696-462",
1239 |       "value": 2
1240 |     },
1241 |     {
1242 |       "source": "Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones",
1243 |       "target": "161-487-188-181-03X",
1244 |       "value": 2
1245 |     },
1246 |     {
1247 |       "source": "Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones",
1248 |       "target": "156-653-831-632-101",
1249 |       "value": 2
1250 |     },
1251 |     {
1252 |       "source": "Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones",
1253 |       "target": "198-017-973-913-570",
1254 |       "value": 2
1255 |     },
1256 |     {
1257 |       "source": "Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones",
1258 |       "target": "076-538-237-089-675",
1259 |       "value": 2
1260 |     },
1261 |     {
1262 |       "source": "Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones",
1263 |       "target": "198-017-973-913-570",
1264 |       "value": 2
1265 |     },
1266 |     {
1267 |       "source": "Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones",
1268 |       "target": "076-538-237-089-675",
1269 |       "value": 2
1270 |     },
1271 |     {
1272 |       "source": "Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones",
1273 |       "target": "051-324-518-696-462",
1274 |       "value": 2
1275 |     },
1276 |     {
1277 |       "source": "Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones",
1278 |       "target": "161-487-188-181-03X",
1279 |       "value": 2
1280 |     },
1281 |     {
1282 |       "source": "Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones",
1283 |       "target": "156-653-831-632-101",
1284 |       "value": 2
1285 |     },
1286 |     {
1287 |       "source": "A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways",
1288 |       "target": "049-222-171-973-678",
1289 |       "value": 2
1290 |     },
1291 |     {
1292 |       "source": "A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways",
1293 |       "target": "074-598-665-914-143",
1294 |       "value": 2
1295 |     },
1296 |     {
1297 |       "source": "X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor",
1298 |       "target": "161-487-188-181-03X",
1299 |       "value": 2
1300 |     },
1301 |     {
1302 |       "source": "X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor",
1303 |       "target": "156-653-831-632-101",
1304 |       "value": 2
1305 |     },
1306 |     {
1307 |       "source": "X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor",
1308 |       "target": "051-324-518-696-462",
1309 |       "value": 2
1310 |     },
1311 |     {
1312 |       "source": "The endosome-lysosome pathway and information generation in the immune system.",
1313 |       "target": "190-195-697-065-907",
1314 |       "value": 2
1315 |     },
1316 |     {
1317 |       "source": "The endosome-lysosome pathway and information generation in the immune system.",
1318 |       "target": "031-461-589-086-771",
1319 |       "value": 2
1320 |     },
1321 |     {
1322 |       "source": "GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor.",
1323 |       "target": "167-851-091-520-257",
1324 |       "value": 2
1325 |     },
1326 |     {
1327 |       "source": "Structure of the TatC core of the twin-arginine protein transport system",
1328 |       "target": "151-760-923-304-502",
1329 |       "value": 2
1330 |     },
1331 |     {
1332 |       "source": "The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase",
1333 |       "target": "097-019-537-894-104",
1334 |       "value": 2
1335 |     },
1336 |     {
1337 |       "source": "The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase",
1338 |       "target": "170-696-774-214-700",
1339 |       "value": 2
1340 |     },
1341 |     {
1342 |       "source": "Application of a novel highly sensitive activity-based probe for detection of cathepsin G",
1343 |       "target": "084-807-525-209-072",
1344 |       "value": 2
1345 |     },
1346 |     {
1347 |       "source": "Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics",
1348 |       "target": "044-648-704-787-12X",
1349 |       "value": 2
1350 |     },
1351 |     {
1352 |       "source": "PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65",
1353 |       "target": "001-353-214-346-040",
1354 |       "value": 2
1355 |     },
1356 |     {
1357 |       "source": "PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65",
1358 |       "target": "150-822-190-827-131",
1359 |       "value": 2
1360 |     },
1361 |     {
1362 |       "source": "PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65",
1363 |       "target": "051-919-508-851-10X",
1364 |       "value": 2
1365 |     },
1366 |     {
1367 |       "source": "Synthesis, Chemical Reactivity as Michael Acceptors, and Biological Potency of Monocyclic Cyanoenones, Novel and Highly Potent Anti-inflammatory and Cytoprotective Agents(1)",
1368 |       "target": "036-789-224-520-054",
1369 |       "value": 2
1370 |     },
1371 |     {
1372 |       "source": "Synthesis, Chemical Reactivity as Michael Acceptors, and Biological Potency of Monocyclic Cyanoenones, Novel and Highly Potent Anti-inflammatory and Cytoprotective Agents(1)",
1373 |       "target": "036-251-116-198-69X",
1374 |       "value": 2
1375 |     },
1376 |     {
1377 |       "source": "Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors",
1378 |       "target": "149-946-446-737-586",
1379 |       "value": 2
1380 |     },
1381 |     {
1382 |       "source": "Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors",
1383 |       "target": "075-397-286-033-085",
1384 |       "value": 2
1385 |     },
1386 |     {
1387 |       "source": "Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors",
1388 |       "target": "028-992-308-265-357",
1389 |       "value": 2
1390 |     },
1391 |     {
1392 |       "source": "Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors",
1393 |       "target": "044-207-676-689-405",
1394 |       "value": 2
1395 |     },
1396 |     {
1397 |       "source": "Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors",
1398 |       "target": "030-350-713-791-200",
1399 |       "value": 2
1400 |     },
1401 |     {
1402 |       "source": "Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach.",
1403 |       "target": "093-997-239-092-949",
1404 |       "value": 2
1405 |     },
1406 |     {
1407 |       "source": "Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach.",
1408 |       "target": "046-345-437-716-689",
1409 |       "value": 2
1410 |     },
1411 |     {
1412 |       "source": "Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach.",
1413 |       "target": "146-411-731-640-871",
1414 |       "value": 2
1415 |     },
1416 |     {
1417 |       "source": "Chemical Proteomic Analysis Reveals the Drugability of the Kinome of Trypanosoma brucei",
1418 |       "target": "000-266-572-036-366",
1419 |       "value": 2
1420 |     },
1421 |     {
1422 |       "source": "Avirulence Protein 3a (AVR3a) from the Potato Pathogen Phytophthora infestans Forms Homodimers through Its Predicted Translocation Region and Does Not Specifically Bind Phospholipids",
1423 |       "target": "186-389-876-954-313",
1424 |       "value": 2
1425 |     },
1426 |     {
1427 |       "source": "NEDD8 overexpression results in neddylation of ubiquitin substrates by the ubiquitin pathway.",
1428 |       "target": "168-483-508-794-377",
1429 |       "value": 2
1430 |     },
1431 |     {
1432 |       "source": "Kinome-wide Selectivity Profiling of ATP-competitive Mammalian Target of Rapamycin (mTOR) Inhibitors and Characterization of Their Binding Kinetics",
1433 |       "target": "029-748-240-628-036",
1434 |       "value": 2
1435 |     },
1436 |     {
1437 |       "source": "The ubiquitin E1 enzyme Ube1 mediates NEDD8 activation under diverse stress conditions",
1438 |       "target": "184-507-509-452-559",
1439 |       "value": 2
1440 |     },
1441 |     {
1442 |       "source": "Acinetobacter baumannii FolD ligand complexes – potent inhibitors of folate metabolism and a re‐evaluation of the structure of LY374571",
1443 |       "target": "069-961-069-943-549",
1444 |       "value": 2
1445 |     },
1446 |     {
1447 |       "source": "Aurora kinase inhibitors: Progress towards the clinic",
1448 |       "target": "017-777-392-752-199",
1449 |       "value": 2
1450 |     },
1451 |     {
1452 |       "source": "Aurora kinase inhibitors: Progress towards the clinic",
1453 |       "target": "000-150-893-948-804",
1454 |       "value": 2
1455 |     },
1456 |     {
1457 |       "source": "Aurora kinase inhibitors: Progress towards the clinic",
1458 |       "target": "027-437-502-794-894",
1459 |       "value": 2
1460 |     },
1461 |     {
1462 |       "source": "Aurora kinase inhibitors: Progress towards the clinic",
1463 |       "target": "074-789-039-135-70X",
1464 |       "value": 2
1465 |     },
1466 |     {
1467 |       "source": "Aurora kinase inhibitors: Progress towards the clinic",
1468 |       "target": "063-617-165-524-327",
1469 |       "value": 2
1470 |     },
1471 |     {
1472 |       "source": "Aurora kinase inhibitors: Progress towards the clinic",
1473 |       "target": "019-872-586-012-269",
1474 |       "value": 2
1475 |     },
1476 |     {
1477 |       "source": "Aurora kinase inhibitors: Progress towards the clinic",
1478 |       "target": "103-648-347-913-447",
1479 |       "value": 2
1480 |     },
1481 |     {
1482 |       "source": "Aurora kinase inhibitors: Progress towards the clinic",
1483 |       "target": "007-245-406-573-328",
1484 |       "value": 2
1485 |     },
1486 |     {
1487 |       "source": "Aurora kinase inhibitors: Progress towards the clinic",
1488 |       "target": "027-437-502-794-894",
1489 |       "value": 2
1490 |     },
1491 |     {
1492 |       "source": "Aurora kinase inhibitors: Progress towards the clinic",
1493 |       "target": "008-337-248-044-723",
1494 |       "value": 2
1495 |     },
1496 |     {
1497 |       "source": "Aurora kinase inhibitors: Progress towards the clinic",
1498 |       "target": "197-071-041-313-103",
1499 |       "value": 2
1500 |     },
1501 |     {
1502 |       "source": "Aurora kinase inhibitors: Progress towards the clinic",
1503 |       "target": "098-538-513-984-747",
1504 |       "value": 2
1505 |     },
1506 |     {
1507 |       "source": "The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser(358) in adipocytes",
1508 |       "target": "019-125-805-246-964",
1509 |       "value": 2
1510 |     },
1511 |     {
1512 |       "source": "The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser(358) in adipocytes",
1513 |       "target": "172-064-016-145-117",
1514 |       "value": 2
1515 |     },
1516 |     {
1517 |       "source": "The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser(358) in adipocytes",
1518 |       "target": "007-417-942-335-284",
1519 |       "value": 2
1520 |     },
1521 |     {
1522 |       "source": "Synergy of Peptide and Sugar in O-GlcNAcase Substrate Recognition",
1523 |       "target": "005-947-025-410-764",
1524 |       "value": 2
1525 |     },
1526 |     {
1527 |       "source": "Synergy of Peptide and Sugar in O-GlcNAcase Substrate Recognition",
1528 |       "target": "116-404-026-640-450",
1529 |       "value": 2
1530 |     },
1531 |     {
1532 |       "source": "Discovery of potent and selective covalent inhibitors of JNK",
1533 |       "target": "090-437-295-781-023",
1534 |       "value": 2
1535 |     },
1536 |     {
1537 |       "source": "Discovery of potent and selective covalent inhibitors of JNK",
1538 |       "target": "197-158-559-918-854",
1539 |       "value": 2
1540 |     },
1541 |     {
1542 |       "source": "Discovery of potent and selective covalent inhibitors of JNK",
1543 |       "target": "076-225-263-850-117",
1544 |       "value": 2
1545 |     },
1546 |     {
1547 |       "source": "Discovery of potent and selective covalent inhibitors of JNK",
1548 |       "target": "049-199-509-181-561",
1549 |       "value": 2
1550 |     },
1551 |     {
1552 |       "source": "Discovery of potent and selective covalent inhibitors of JNK",
1553 |       "target": "179-045-041-176-506",
1554 |       "value": 2
1555 |     },
1556 |     {
1557 |       "source": "Discovery of potent and selective covalent inhibitors of JNK",
1558 |       "target": "004-301-778-674-378",
1559 |       "value": 2
1560 |     },
1561 |     {
1562 |       "source": "Phosphorylation of FOXO3a on Ser-7 by p38 Promotes Its Nuclear Localization in Response to Doxorubicin",
1563 |       "target": "111-313-231-732-367",
1564 |       "value": 2
1565 |     },
1566 |     {
1567 |       "source": "AMPK: a nutrient and energy sensor that maintains energy homeostasis",
1568 |       "target": "092-197-031-561-353",
1569 |       "value": 2
1570 |     },
1571 |     {
1572 |       "source": "AMPK: a nutrient and energy sensor that maintains energy homeostasis",
1573 |       "target": "192-019-786-423-841",
1574 |       "value": 2
1575 |     },
1576 |     {
1577 |       "source": "AMPK: a nutrient and energy sensor that maintains energy homeostasis",
1578 |       "target": "192-019-786-423-841",
1579 |       "value": 2
1580 |     },
1581 |     {
1582 |       "source": "AMPK: a nutrient and energy sensor that maintains energy homeostasis",
1583 |       "target": "076-608-180-638-59X",
1584 |       "value": 2
1585 |     },
1586 |     {
1587 |       "source": "AMPK: a nutrient and energy sensor that maintains energy homeostasis",
1588 |       "target": "175-263-797-963-040",
1589 |       "value": 2
1590 |     },
1591 |     {
1592 |       "source": "AMPK: a nutrient and energy sensor that maintains energy homeostasis",
1593 |       "target": "092-197-031-561-353",
1594 |       "value": 2
1595 |     },
1596 |     {
1597 |       "source": "Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases.",
1598 |       "target": "141-694-167-791-759",
1599 |       "value": 2
1600 |     },
1601 |     {
1602 |       "source": "Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases.",
1603 |       "target": "081-203-444-563-604",
1604 |       "value": 2
1605 |     },
1606 |     {
1607 |       "source": "Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases.",
1608 |       "target": "125-348-249-762-351",
1609 |       "value": 2
1610 |     },
1611 |     {
1612 |       "source": "Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases.",
1613 |       "target": "125-850-986-196-787",
1614 |       "value": 2
1615 |     },
1616 |     {
1617 |       "source": "Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction",
1618 |       "target": "119-397-162-706-860",
1619 |       "value": 2
1620 |     },
1621 |     {
1622 |       "source": "Small molecules that bind the Mdm2 RING stabilize and activate p53",
1623 |       "target": "133-023-408-974-285",
1624 |       "value": 2
1625 |     },
1626 |     {
1627 |       "source": "Small molecules that bind the Mdm2 RING stabilize and activate p53",
1628 |       "target": "039-847-299-166-952",
1629 |       "value": 2
1630 |     },
1631 |     {
1632 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1633 |       "target": "076-641-402-312-988",
1634 |       "value": 2
1635 |     },
1636 |     {
1637 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1638 |       "target": "102-485-198-725-150",
1639 |       "value": 2
1640 |     },
1641 |     {
1642 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1643 |       "target": "168-829-456-947-639",
1644 |       "value": 2
1645 |     },
1646 |     {
1647 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1648 |       "target": "098-813-369-162-741",
1649 |       "value": 2
1650 |     },
1651 |     {
1652 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1653 |       "target": "023-180-369-416-862",
1654 |       "value": 2
1655 |     },
1656 |     {
1657 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1658 |       "target": "189-473-046-734-005",
1659 |       "value": 2
1660 |     },
1661 |     {
1662 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1663 |       "target": "019-633-684-883-828",
1664 |       "value": 2
1665 |     },
1666 |     {
1667 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1668 |       "target": "174-501-376-407-235",
1669 |       "value": 2
1670 |     },
1671 |     {
1672 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1673 |       "target": "129-062-448-949-030",
1674 |       "value": 2
1675 |     },
1676 |     {
1677 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1678 |       "target": "162-916-741-322-002",
1679 |       "value": 2
1680 |     },
1681 |     {
1682 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1683 |       "target": "080-026-305-809-343",
1684 |       "value": 2
1685 |     },
1686 |     {
1687 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1688 |       "target": "016-698-167-713-829",
1689 |       "value": 2
1690 |     },
1691 |     {
1692 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1693 |       "target": "091-325-080-234-401",
1694 |       "value": 2
1695 |     },
1696 |     {
1697 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1698 |       "target": "032-206-614-235-635",
1699 |       "value": 2
1700 |     },
1701 |     {
1702 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1703 |       "target": "143-271-017-351-983",
1704 |       "value": 2
1705 |     },
1706 |     {
1707 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1708 |       "target": "169-312-245-869-778",
1709 |       "value": 2
1710 |     },
1711 |     {
1712 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1713 |       "target": "089-818-979-077-305",
1714 |       "value": 2
1715 |     },
1716 |     {
1717 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1718 |       "target": "187-517-157-601-239",
1719 |       "value": 2
1720 |     },
1721 |     {
1722 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1723 |       "target": "111-583-988-147-450",
1724 |       "value": 2
1725 |     },
1726 |     {
1727 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1728 |       "target": "058-026-435-099-506",
1729 |       "value": 2
1730 |     },
1731 |     {
1732 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1733 |       "target": "153-651-762-444-327",
1734 |       "value": 2
1735 |     },
1736 |     {
1737 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1738 |       "target": "159-766-711-047-610",
1739 |       "value": 2
1740 |     },
1741 |     {
1742 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1743 |       "target": "058-933-099-316-100",
1744 |       "value": 2
1745 |     },
1746 |     {
1747 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1748 |       "target": "023-452-662-674-373",
1749 |       "value": 2
1750 |     },
1751 |     {
1752 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1753 |       "target": "047-432-030-246-04X",
1754 |       "value": 2
1755 |     },
1756 |     {
1757 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1758 |       "target": "139-008-712-602-518",
1759 |       "value": 2
1760 |     },
1761 |     {
1762 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1763 |       "target": "137-720-748-139-162",
1764 |       "value": 2
1765 |     },
1766 |     {
1767 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1768 |       "target": "192-136-893-476-749",
1769 |       "value": 2
1770 |     },
1771 |     {
1772 |       "source": "Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice",
1773 |       "target": "172-890-893-515-719",
1774 |       "value": 2
1775 |     },
1776 |     {
1777 |       "source": "AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern",
1778 |       "target": "104-472-615-006-481",
1779 |       "value": 2
1780 |     },
1781 |     {
1782 |       "source": "AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern",
1783 |       "target": "097-374-332-908-898",
1784 |       "value": 2
1785 |     },
1786 |     {
1787 |       "source": "AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern",
1788 |       "target": "034-416-075-094-770",
1789 |       "value": 2
1790 |     },
1791 |     {
1792 |       "source": "AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern",
1793 |       "target": "127-642-274-375-054",
1794 |       "value": 2
1795 |     },
1796 |     {
1797 |       "source": "AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern",
1798 |       "target": "036-708-909-192-156",
1799 |       "value": 2
1800 |     },
1801 |     {
1802 |       "source": "AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern",
1803 |       "target": "193-863-590-855-263",
1804 |       "value": 2
1805 |     },
1806 |     {
1807 |       "source": "AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern",
1808 |       "target": "150-028-859-997-047",
1809 |       "value": 2
1810 |     },
1811 |     {
1812 |       "source": "AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern",
1813 |       "target": "034-416-075-094-770",
1814 |       "value": 2
1815 |     },
1816 |     {
1817 |       "source": "AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern",
1818 |       "target": "097-374-332-908-898",
1819 |       "value": 2
1820 |     },
1821 |     {
1822 |       "source": "AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern",
1823 |       "target": "104-472-615-006-481",
1824 |       "value": 2
1825 |     },
1826 |     {
1827 |       "source": "AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern",
1828 |       "target": "132-394-716-226-832",
1829 |       "value": 2
1830 |     },
1831 |     {
1832 |       "source": "Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes",
1833 |       "target": "168-483-508-794-377",
1834 |       "value": 2
1835 |     },
1836 |     {
1837 |       "source": "Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.",
1838 |       "target": "131-238-819-455-784",
1839 |       "value": 2
1840 |     },
1841 |     {
1842 |       "source": "Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.",
1843 |       "target": "155-402-461-387-483",
1844 |       "value": 2
1845 |     },
1846 |     {
1847 |       "source": "Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.",
1848 |       "target": "040-389-070-176-191",
1849 |       "value": 2
1850 |     },
1851 |     {
1852 |       "source": "Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.",
1853 |       "target": "076-478-479-475-120",
1854 |       "value": 2
1855 |     },
1856 |     {
1857 |       "source": "A multifunctional protease inhibitor to regulate endolysosomal function.",
1858 |       "target": "031-461-589-086-771",
1859 |       "value": 2
1860 |     },
1861 |     {
1862 |       "source": "A multifunctional protease inhibitor to regulate endolysosomal function.",
1863 |       "target": "190-195-697-065-907",
1864 |       "value": 2
1865 |     },
1866 |     {
1867 |       "source": "Design, Synthesis, and Structure−Activity Relationship Exploration of 1-Substituted 4-Aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one Analogues as Inhibitors of the Annexin A2−S100A10 Protein Interaction",
1868 |       "target": "034-190-802-321-708",
1869 |       "value": 2
1870 |     },
1871 |     {
1872 |       "source": "4-benzimidazolyl-3-phenylbutanoic acids as novel PIF-pocket-targeting allosteric inhibitors of protein kinase PKCζ.",
1873 |       "target": "130-316-719-983-242",
1874 |       "value": 2
1875 |     },
1876 |     {
1877 |       "source": "Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors",
1878 |       "target": "076-478-479-475-120",
1879 |       "value": 2
1880 |     },
1881 |     {
1882 |       "source": "Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors",
1883 |       "target": "040-389-070-176-191",
1884 |       "value": 2
1885 |     },
1886 |     {
1887 |       "source": "Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors",
1888 |       "target": "036-668-261-470-040",
1889 |       "value": 2
1890 |     },
1891 |     {
1892 |       "source": "Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors",
1893 |       "target": "183-767-289-461-131",
1894 |       "value": 2
1895 |     },
1896 |     {
1897 |       "source": "Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1",
1898 |       "target": "107-556-164-321-147",
1899 |       "value": 2
1900 |     },
1901 |     {
1902 |       "source": "The inhibitory effect of phospholemman on the sodium pump requires its palmitoylation.",
1903 |       "target": "106-594-488-484-12X",
1904 |       "value": 2
1905 |     },
1906 |     {
1907 |       "source": "SCF/β-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a keap1-independent manner",
1908 |       "target": "066-190-726-252-149",
1909 |       "value": 2
1910 |     },
1911 |     {
1912 |       "source": "Immunosuppressive but Non-LasR-Inducing Analogues of the Pseudomonas aeruginosa Quorum-Sensing Molecule N-(3-Oxododecanoyl)-L-homoserine Lactone",
1913 |       "target": "140-900-012-438-14X",
1914 |       "value": 2
1915 |     },
1916 |     {
1917 |       "source": "Absolute SILAC-Compatible Expression Strain Allows Sumo-2 Copy Number Determination in Clinical Samples",
1918 |       "target": "058-438-690-312-096",
1919 |       "value": 2
1920 |     },
1921 |     {
1922 |       "source": "Absolute SILAC-Compatible Expression Strain Allows Sumo-2 Copy Number Determination in Clinical Samples",
1923 |       "target": "004-889-112-130-518",
1924 |       "value": 2
1925 |     },
1926 |     {
1927 |       "source": "Collateral sensitivity of multidrug-resistant cells to the orphan drug tiopronin.",
1928 |       "target": "193-040-307-473-220",
1929 |       "value": 2
1930 |     },
1931 |     {
1932 |       "source": "Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2",
1933 |       "target": "188-718-220-131-362",
1934 |       "value": 2
1935 |     },
1936 |     {
1937 |       "source": "Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2",
1938 |       "target": "087-577-350-425-176",
1939 |       "value": 2
1940 |     },
1941 |     {
1942 |       "source": "Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2",
1943 |       "target": "191-670-060-004-126",
1944 |       "value": 2
1945 |     },
1946 |     {
1947 |       "source": "Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2",
1948 |       "target": "188-803-921-043-695",
1949 |       "value": 2
1950 |     },
1951 |     {
1952 |       "source": "Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2",
1953 |       "target": "041-699-843-843-567",
1954 |       "value": 2
1955 |     },
1956 |     {
1957 |       "source": "Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2",
1958 |       "target": "180-366-233-781-99X",
1959 |       "value": 2
1960 |     },
1961 |     {
1962 |       "source": "Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2",
1963 |       "target": "156-653-831-632-101",
1964 |       "value": 2
1965 |     },
1966 |     {
1967 |       "source": "Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2",
1968 |       "target": "051-324-518-696-462",
1969 |       "value": 2
1970 |     },
1971 |     {
1972 |       "source": "Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2",
1973 |       "target": "161-487-188-181-03X",
1974 |       "value": 2
1975 |     },
1976 |     {
1977 |       "source": "Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2",
1978 |       "target": "167-851-091-520-257",
1979 |       "value": 2
1980 |     },
1981 |     {
1982 |       "source": "Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2",
1983 |       "target": "122-739-962-072-793",
1984 |       "value": 2
1985 |     },
1986 |     {
1987 |       "source": "ATP site-directed inhibitors of protein kinase CK2: an update.",
1988 |       "target": "109-274-898-147-341",
1989 |       "value": 2
1990 |     },
1991 |     {
1992 |       "source": "Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3",
1993 |       "target": "124-179-501-005-870",
1994 |       "value": 2
1995 |     },
1996 |     {
1997 |       "source": "Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3",
1998 |       "target": "008-694-981-426-172",
1999 |       "value": 2
2000 |     },
2001 |     {
2002 |       "source": "Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3",
2003 |       "target": "109-611-546-954-080",
2004 |       "value": 2
2005 |     },
2006 |     {
2007 |       "source": "Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon β.",
2008 |       "target": "004-378-254-734-355",
2009 |       "value": 2
2010 |     },
2011 |     {
2012 |       "source": "Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon β.",
2013 |       "target": "133-997-520-845-569",
2014 |       "value": 2
2015 |     },
2016 |     {
2017 |       "source": "Substrate and Product Analogues as Human O-Glcnac Transferase Inhibitors.",
2018 |       "target": "115-381-943-359-61X",
2019 |       "value": 2
2020 |     },
2021 |     {
2022 |       "source": "Substrate and Product Analogues as Human O-Glcnac Transferase Inhibitors.",
2023 |       "target": "022-078-711-389-998",
2024 |       "value": 2
2025 |     },
2026 |     {
2027 |       "source": "Substrate and Product Analogues as Human O-Glcnac Transferase Inhibitors.",
2028 |       "target": "132-854-391-972-865",
2029 |       "value": 2
2030 |     },
2031 |     {
2032 |       "source": "Substrate and Product Analogues as Human O-Glcnac Transferase Inhibitors.",
2033 |       "target": "171-143-110-884-468",
2034 |       "value": 2
2035 |     },
2036 |     {
2037 |       "source": "The cytoprotective role of the Keap1–Nrf2 pathway",
2038 |       "target": "003-946-199-636-328",
2039 |       "value": 2
2040 |     },
2041 |     {
2042 |       "source": "The cytoprotective role of the Keap1–Nrf2 pathway",
2043 |       "target": "009-649-401-227-606",
2044 |       "value": 2
2045 |     },
2046 |     {
2047 |       "source": "The cytoprotective role of the Keap1–Nrf2 pathway",
2048 |       "target": "170-042-571-881-121",
2049 |       "value": 2
2050 |     },
2051 |     {
2052 |       "source": "The cytoprotective role of the Keap1–Nrf2 pathway",
2053 |       "target": "033-301-273-471-462",
2054 |       "value": 2
2055 |     },
2056 |     {
2057 |       "source": "The cytoprotective role of the Keap1–Nrf2 pathway",
2058 |       "target": "040-826-560-477-838",
2059 |       "value": 2
2060 |     },
2061 |     {
2062 |       "source": "The cytoprotective role of the Keap1–Nrf2 pathway",
2063 |       "target": "048-208-660-423-215",
2064 |       "value": 2
2065 |     },
2066 |     {
2067 |       "source": "The cytoprotective role of the Keap1–Nrf2 pathway",
2068 |       "target": "135-293-472-746-415",
2069 |       "value": 2
2070 |     },
2071 |     {
2072 |       "source": "Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors",
2073 |       "target": "153-999-081-812-523",
2074 |       "value": 2
2075 |     },
2076 |     {
2077 |       "source": "Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors",
2078 |       "target": "000-498-778-953-787",
2079 |       "value": 2
2080 |     },
2081 |     {
2082 |       "source": "Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors",
2083 |       "target": "085-065-777-135-758",
2084 |       "value": 2
2085 |     },
2086 |     {
2087 |       "source": "Analgesic omega-Conotoxins CVIE and CVIF Selectively and Voltage-Dependently Block Recombinant and Native N-Type Calcium Channels (vol 77, pg 139, 2010)",
2088 |       "target": "152-366-692-522-975",
2089 |       "value": 2
2090 |     },
2091 |     {
2092 |       "source": "Analgesic omega-Conotoxins CVIE and CVIF Selectively and Voltage-Dependently Block Recombinant and Native N-Type Calcium Channels (vol 77, pg 139, 2010)",
2093 |       "target": "167-869-142-610-582",
2094 |       "value": 2
2095 |     },
2096 |     {
2097 |       "source": "NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration",
2098 |       "target": "191-676-336-200-724",
2099 |       "value": 2
2100 |     },
2101 |     {
2102 |       "source": "Development of 18F-fluorinatable dendrons and their application to cancer cell targeting",
2103 |       "target": "056-387-403-639-935",
2104 |       "value": 2
2105 |     },
2106 |     {
2107 |       "source": "The specificities of small molecule inhibitors of the TGFß and BMP pathways",
2108 |       "target": "066-841-401-628-941",
2109 |       "value": 2
2110 |     },
2111 |     {
2112 |       "source": "The specificities of small molecule inhibitors of the TGFß and BMP pathways",
2113 |       "target": "069-503-782-573-055",
2114 |       "value": 2
2115 |     },
2116 |     {
2117 |       "source": "The specificities of small molecule inhibitors of the TGFß and BMP pathways",
2118 |       "target": "028-137-796-142-577",
2119 |       "value": 2
2120 |     },
2121 |     {
2122 |       "source": "Catalysis by the nucleolytic ribozymes",
2123 |       "target": "197-678-301-596-236",
2124 |       "value": 2
2125 |     },
2126 |     {
2127 |       "source": "Catalysis by the nucleolytic ribozymes",
2128 |       "target": "147-466-934-435-143",
2129 |       "value": 2
2130 |     },
2131 |     {
2132 |       "source": "Catalysis by the nucleolytic ribozymes",
2133 |       "target": "114-647-123-099-321",
2134 |       "value": 2
2135 |     },
2136 |     {
2137 |       "source": "Catalysis by the nucleolytic ribozymes",
2138 |       "target": "058-829-130-504-901",
2139 |       "value": 2
2140 |     },
2141 |     {
2142 |       "source": "Catalysis by the nucleolytic ribozymes",
2143 |       "target": "169-953-034-717-264",
2144 |       "value": 2
2145 |     },
2146 |     {
2147 |       "source": "Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1",
2148 |       "target": "028-012-588-449-727",
2149 |       "value": 2
2150 |     },
2151 |     {
2152 |       "source": "Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1",
2153 |       "target": "038-839-140-589-623",
2154 |       "value": 2
2155 |     },
2156 |     {
2157 |       "source": "N1-Benzyl substituted cambinol analogues as isozyme selective inhibitors of the sirtuin family of protein deacetylases",
2158 |       "target": "194-924-906-201-593",
2159 |       "value": 2
2160 |     },
2161 |     {
2162 |       "source": "N1-Benzyl substituted cambinol analogues as isozyme selective inhibitors of the sirtuin family of protein deacetylases",
2163 |       "target": "195-611-964-620-410",
2164 |       "value": 2
2165 |     },
2166 |     {
2167 |       "source": "N1-Benzyl substituted cambinol analogues as isozyme selective inhibitors of the sirtuin family of protein deacetylases",
2168 |       "target": "025-014-524-538-421",
2169 |       "value": 2
2170 |     },
2171 |     {
2172 |       "source": "N1-Benzyl substituted cambinol analogues as isozyme selective inhibitors of the sirtuin family of protein deacetylases",
2173 |       "target": "025-014-524-538-421",
2174 |       "value": 2
2175 |     },
2176 |     {
2177 |       "source": "AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function",
2178 |       "target": "120-667-268-642-909",
2179 |       "value": 2
2180 |     },
2181 |     {
2182 |       "source": "AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function",
2183 |       "target": "163-117-320-460-138",
2184 |       "value": 2
2185 |     },
2186 |     {
2187 |       "source": "AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function",
2188 |       "target": "191-290-593-697-506",
2189 |       "value": 2
2190 |     },
2191 |     {
2192 |       "source": "AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function",
2193 |       "target": "118-339-847-530-982",
2194 |       "value": 2
2195 |     },
2196 |     {
2197 |       "source": "AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function",
2198 |       "target": "073-318-370-112-877",
2199 |       "value": 2
2200 |     },
2201 |     {
2202 |       "source": "AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function",
2203 |       "target": "113-828-920-381-078",
2204 |       "value": 2
2205 |     },
2206 |     {
2207 |       "source": "AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function",
2208 |       "target": "048-983-957-537-421",
2209 |       "value": 2
2210 |     },
2211 |     {
2212 |       "source": "Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488",
2213 |       "target": "073-531-962-083-670",
2214 |       "value": 2
2215 |     }
2216 |   ]
2217 | }
2218 | 


--------------------------------------------------------------------------------
/index.html:
--------------------------------------------------------------------------------
 1 | <!DOCTYPE html>
 2 | <html lang="en">
 3 |   <head>
 4 |     <script src="https://cdnjs.cloudflare.com/ajax/libs/p5.js/1.3.1/p5.min.js"></script>
 5 |     <script src="https://cdnjs.cloudflare.com/ajax/libs/d3/7.0.0/d3.min.js" integrity="sha512-0x7/VCkKLLt4wnkFqI8Cgv6no+AaS1TDgmHLOoU3hy/WVtYta2J6gnOIHhYYDJlDxPqEqAYLPS4gzVex4mGJLw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script>
 6 |     <meta charset="utf-8" />
 7 | 
 8 |   </head>
 9 |   <body>
10 |     <script src="sketch.js"></script>
11 |   </body>
12 | </html>
13 | 


--------------------------------------------------------------------------------
/sketch.js:
--------------------------------------------------------------------------------
  1 | let data;
  2 | let nodes, links;
  3 | let simulation;
  4 | let radius = 4;
  5 | 
  6 | function preload() {
  7 |   data = loadJSON("yt-data.json");
  8 | }
  9 | 
 10 | function findSubject(mouseX, mouseY) {
 11 |   let subject = null;
 12 |   let distance = Infinity;
 13 |   for (const n of nodes) {
 14 |     let d = Math.hypot(mouseX - n.x - width / 2, mouseY - n.y - height / 2);
 15 |     if (d < distance && d < n.radius) {
 16 |       distance = d;
 17 |       subject = n;
 18 |     }
 19 |   }
 20 |   return subject;
 21 | }
 22 | 
 23 | // Finding a node to drag
 24 | let draggedNode = null;
 25 | 
 26 | function mousePressed() {
 27 |   draggedNode = findSubject(mouseX, mouseY);
 28 |   if (draggedNode) simulation.alphaTarget(0.3).restart();
 29 | }
 30 | 
 31 | function mouseReleased() {
 32 |   if (draggedNode) simulation.alphaTarget(0);
 33 |   draggedNode = null;
 34 | }
 35 | 
 36 | function startSimulation() {
 37 |   links = data.links.map((d) => {
 38 |     return Object.create(d);
 39 |   });
 40 |   nodes = data.nodes.map((d) => {
 41 |     d.radius = Number(d.views) / 100;
 42 |     return Object.create(d);
 43 |   });
 44 | 
 45 |   simulation = d3
 46 |     .forceSimulation(nodes)
 47 |     .force(
 48 |       "link",
 49 |       d3
 50 |         .forceLink(links)
 51 |         .id((d) => d.id)
 52 |         .distance((d) => d.value * 20)
 53 |         .strength((d) => d.value / 10)
 54 |     )
 55 |     .force("charge", d3.forceManyBody())
 56 |     .force("x", d3.forceX(0))
 57 |     .force("y", d3.forceY(0));
 58 | 
 59 |   simulation.on("tick", () => {
 60 |     render();
 61 |   });
 62 | }
 63 | 
 64 | let canvas;
 65 | 
 66 | function setup() {
 67 |   createCanvas(600, 600);
 68 | 
 69 |   background(0);
 70 |   startSimulation();
 71 | }
 72 | 
 73 | function render() {
 74 |   background(0);
 75 |   if (draggedNode) {
 76 |     draggedNode.x = mouseX - width / 2;
 77 |     draggedNode.y = mouseY - height / 2;
 78 |   }
 79 | 
 80 |   resetMatrix();
 81 |   translate(width / 2, height / 2);
 82 | 
 83 |   for (let link of links) {
 84 |     const { source, target } = link;
 85 |     stroke(240, 99, 164);
 86 |     strokeWeight(link.value);
 87 |     line(source.x, source.y, target.x, target.y);
 88 |   }
 89 | 
 90 |   let hover = findSubject(mouseX, mouseY);
 91 |   if (hover) {
 92 |     fill(255);
 93 |     noStroke();
 94 |     textAlign(LEFT, CENTER);
 95 |     textSize(32);
 96 |     text(hover.id, hover.x + hover.radius + 10, hover.y);
 97 |   }
 98 | 
 99 |   for (let node of nodes) {
100 |     noStroke();
101 |     fill(45, 197, 244);
102 |     circle(node.x, node.y, node.radius * 2);
103 |   }
104 | }
105 | 


--------------------------------------------------------------------------------
/yt-data.json:
--------------------------------------------------------------------------------
 1 | {
 2 |   "nodes": [
 3 |     {
 4 |       "id": "Self-Avoiding Random Walk",
 5 |       "views": 1000
 6 |     },
 7 |     {
 8 |       "id": "Fractal Tree",
 9 |       "views": 2000
10 |     },
11 |     {
12 |       "id": "Game of Life",
13 |       "views": 500
14 |     },
15 |     {
16 |       "id": "PI Day",
17 |       "views": 2500
18 |     }
19 |   ],
20 |   "links": [
21 |     {
22 |       "source": "Game of Life",
23 |       "target": "Self-Avoiding Random Walk",
24 |       "value": 5
25 |     },
26 |     {
27 |       "source": "Fractal Tree",
28 |       "target": "PI Day",
29 |       "value": 10
30 |     }
31 |   ]
32 | }
33 | 


--------------------------------------------------------------------------------