├── .Rprofile ├── .gitignore ├── ClinVar ├── FreqFilterClinVarSubmission.ExpEvidence.csv ├── FreqFilterClinVarSubmission.SubmissionInfo.csv └── FreqFilterClinVarSubmission.Variant.csv ├── R ├── .Rprofile ├── Figures.R ├── floorEffects.R ├── setup.R └── sumariseCaseSeriesVariants.R ├── README.md ├── data-raw ├── .keep ├── ExACVariants_0.001_sarcomeric.txt ├── HCM_BRU_Variants_and_freqs.txt ├── LMM_OXF_path_likelyPath_VUS_variants_allExACpopulations_withLowestClass.txt ├── SupplementaryTable1.txt ├── Table1.txt ├── Table2.txt └── authors.txt ├── data ├── .keep └── filtering_stats.tsv ├── figures ├── .keep └── Figure1.png ├── frequencyFilter.Rproj ├── manuscript ├── .Rprofile ├── SupplementaryMaterial.Rmd ├── manuscript.Rmd ├── nature.csl ├── newTemplate.docx └── template2.docx ├── packrat ├── init.R ├── packrat.lock ├── packrat.opts └── src │ └── packrat │ └── packrat_0.4.7-1.tar.gz └── src ├── hcm_curation.R ├── precompute_exac_af_filter.R └── vcf_to_var_indiv_table.py /.Rprofile: 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