5 | PREFIX :
6 |
7 | :idShape IRI {
8 | sio:SIO_000020 @:undiagnosedRoleShape ;
9 | a [sio:SIO_000115] ;
10 | sio:SIO_000300 xsd:string ;
11 | rdfs:label xsd:string?
12 | }
13 |
14 | :personShape IRI {
15 | sio:SIO_000228 @:undiagnosedRoleShape ;
16 | sio:SIO_000008 @:genotypeAttributeShape ;
17 | sio:SIO_000008 @:phenotypeAttributeShape ;
18 | sio:SIO_000008 @:undiagnosedAttributeShape ;
19 | a [sio:SIO_000498] ;
20 | rdfs:label xsd:string?
21 | }
22 |
23 | :undiagnosedRoleShape IRI {
24 | sio:SIO_000356 @:undiagnosedProcessShape ;
25 | a [obo:OBI_0000093] ;
26 | a [sio:SIO_000016] ;
27 | rdfs:label xsd:string?
28 | }
29 |
30 | :undiagnosedProcessShape IRI {
31 | sio:SIO_000680 @:undiagnosedEndStartdateShape ;
32 | sio:SIO_000681 @:undiagnosedEndStartdateShape ;
33 | sio:SIO_000229 @:undiagnosedOutputShape ;
34 | sio:SIO_000230 @:genotypeInputShape ;
35 | sio:SIO_000230 @:phenotypeInputShape ;
36 | a [sio:SIO_001001] ;
37 | a [sio:SIO_000006] ;
38 | rdfs:label xsd:string?
39 | }
40 |
41 | :undiagnosedOutputShape IRI {
42 | sio:SIO_000628 @:undiagnosedAttributeShape ;
43 | a [sio:SIO_000015] ;
44 | rdfs:label xsd:string? ;
45 | sio:SIO_000300 xsd:string
46 | }
47 |
48 | :phenotypeInputShape IRI {
49 | sio:SIO_000628 @:phenotypeAttributeShape ;
50 | a [obo:NCIT_C102741] ;
51 | a [sio:SIO_000015] ;
52 | rdfs:label xsd:string? ;
53 | sio:SIO_000300 xsd:string
54 | }
55 |
56 | :genotypeInputShape IRI {
57 | sio:SIO_000628 @:genotypeAttributeShape ;
58 | a [sio:SIO_001388] ;
59 | a [sio:SIO_000015] ;
60 | rdfs:label xsd:string? ;
61 | sio:SIO_000300 xsd:string
62 | }
63 |
64 | :undiagnosedEndStartdateShape IRI {
65 | a [sio:SIO_000031 sio:SIO_000032] ;
66 | rdfs:label xsd:string? ;
67 | sio:SIO_000300 xsd:date
68 | }
69 |
70 | :undiagnosedAttributeShape IRI {
71 | a [obo:NCIT_C113725] ;
72 | a [sio:SIO_000614] ;
73 | rdfs:label xsd:string?
74 | }
75 |
76 | :phenotypeAttributeShape IRI {
77 | a [sio:SIO_000614] ;
78 | a IRI /^http:\/\/purl.obolibrary.org\/obo\/HP_/ ;
79 | rdfs:label xsd:string?
80 | }
81 |
82 | :genotypeAttributeShape IRI /^https:\/\/identifiers.org\// {
83 | a [obo:NCIT_C171178] ;
84 | a [sio:SIO_000614] ;
85 | rdfs:label xsd:string?
86 | }
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/README.md:
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1 |
2 | # Semantic data model of the set of common data elements for rare disease registration
3 | 
4 | 
5 |
6 | > To make rare disease registry data Interoperable (the I in FAIR).
7 |
8 | In this work we present a semantic data model for [the set of common data elements for rare diseases registration](https://eu-rd-platform.jrc.ec.europa.eu/sites/default/files/CDS/EU_RD_Platform_CDS_Final.pdf) recommended by the European commission Joint Research Centre. We proposed a semantic data model for these data elements.
9 |
10 |
11 | # *IMPORTANT ANNOUNCEMENT!*
12 | This Github repository is currently deprecated, The new stable version of this semantic model is maintained as Clinical And Registry Entries (CARE) Semantic Model. This model is maintained at this different [Github registry](https://github.com/ejp-rd-vp/CARE-Semantic-Model)
13 |
14 |
15 | ## CDE modules overview
16 |
17 | The figure below gives an overview of upper level concepts and properties used in our cde model.
18 |
19 |
20 | 
21 |
Figure 1: Common data element overall semantic model
22 |
23 |
24 |
25 |
26 |
27 | 
28 |
Figure 2: Observation context metadata layer
29 |
30 |
31 |
32 |
33 | You can browse different CDE modules by visiting the links below.
34 |
35 | Patient personal information:
36 | * [Birthyear](docs/Birthyear.md) - describes patient year of birth
37 | * [Birthdate](docs/Birthdate.md) - describes patient date of birth
38 | * [Sex](docs/Sex.md) - describes patient sex at birth
39 | * [Body measurement](docs/Body_measurement.md) - describes patient physical measurement of the body.
40 |
41 | Participation status:
42 | * [Status](docs/Status.md) - describes patient alive or dead status
43 | * [Deathdate](docs/Deathdate.md) - describes patient date of death
44 |
45 | Medical history:
46 | * [First confirmed visit](docs/First_visit.md) - describes patient first contact with specialized center
47 | * [Symptoms onset](docs/Symptoms_onset.md) - describes patient signs/symptoms onset
48 |
49 | Conditions and medical findings:
50 | * [Diagnosis](docs/Diagnosis.md) - describes patient disease diagnosis
51 | * [Symptoms and phenotype assessment](docs/Symptoms.md) - describes patient date of signs/symptoms and its onset
52 | * [Genetic information](docs/Genotype.md) - describes genetic diagnosis retained by the specialized center
53 | * [Disability](docs/Disability.md) - describes patient disability score
54 | * [Laboratory Measurement](docs/Laboratory.md) - describes patient laboratory measurements.
55 | * [Imaging](docs/Imaging.md) - capture any patient medical imaging data.
56 |
57 | Research availability and consent:
58 | * [Biobank](docs/Biobank.md) - describes availability of subject's samples in a biobank
59 | * [Consent](docs/Consent.md) - describes consent given by a subject
60 |
61 | Treatment-related interventions:
62 | * [Medications](docs/Medication.md) - describes patient medications based on a prescription.
63 | * [Treatment/Therapy](docs/Intervention.md) - describes any component presented in treatment and therapy procedures.
64 |
65 | Clinical trials:
66 | * [Clinical Trials](docs/Clinical_trials.md) - describes patient participation in clinical trials.
67 |
68 | ## Moving to the new version 2.0.0
69 |
70 | While considerable time was spent on the first generation of CDE models, the final published set remained inconsistent in a number of ways:
71 |
72 | 1) Nodes had different numbers of ontological annotations, with no justification
73 | 2) The CDE models adopted the high-level CDEs defined by the RD Platform, which were often aggregations of individual data elements. As a consequence:
74 |
75 | a) Registries did not always have all of the individual subcomponents to fulfil the model
76 |
77 | b) It was unclear what to do when a model couldn't be filled
78 |
79 | c) This led to data loss, when those data elements were not FAIR-transformed
80 |
81 | 3) Date/time were sometimes included in the model, and sometimes not
82 | 4) The CSV files all had a distinct structure, meaning each one needed fairly specialized code to generate. For more information about how to implement our CDE semantic model, click [here](https://github.com/ejp-rd-vp/CDE-semantic-model-implementations).
83 | 5) There was no easy way to aggregate various observations together that might be related (e.g. the observations/interventions made during the course of a COVID infection)
84 |
85 | ## Features of the new version:
86 |
87 | 1) The overall model is identical to the original Core CDE model ([Figure 1](/Images/0.Unified_CDE_model.png)).
88 | 2) Only one data element is modeled at a time; if you do not have that element, you do not use that model
89 | 3) Every element of the model has an "upper ontology" type (e.g. "process") and a domain-specific type (e.g. "blood pressure measurement process"). Exactly two types per node.
90 | 4) Date/Time is now considered metadata of the data model. Even in the case where date/time are the core observation of the model (e.g. date of symptom onset) Thus, all models are identical in structure and metadata ([Figure 2](/Images/context_metadata.png)).
91 | 5) This metadata takes the form of a "context" node (i.e. an RDF Quad, rather than an RDF Triple), which is annotated with various things. In addition, the context node becomes "part of" a patient's overall timeline, which itself is modeled in RDF and creates a larger grouping of all observations about a patient.
92 | 6) In addition to being "part of" a patient's timeline, context nodes _can be_ grouped into other arbitrary collections reflecting other kinds of groupings (like the COVID-19 infection scenario described above). Its not mandatory to implement this in your model - it is merely made possible by this new model, which was not the case with the Version 1 models.
93 |
94 |
95 | ## Cite us
96 | To cite this model please use this publication [Semantic modeling of common data elements for rare disease registries, and a prototype workflow for their deployment over registry data](https://doi.org/10.1186/s13326-022-00264-6).
97 |
98 | ## Acknowledgement
99 | This work was done in the [European Joint Programme on Rare Diseases (EJP RD)](https://www.ejprarediseases.org/) project which has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement N°82557.
100 | 
101 |
102 |
103 |
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/docs/Biobank.md:
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1 | This module describes the data elements related to biological samples stored in a biobank. It specifically covers the CDE elements 7.3.'Biological Sample' and 7.4.'Link to a biobank'.
2 | These elements, defined by the JRC, can be found on the EU RD Platform at [this link](https://eu-rd-platform.jrc.ec.europa.eu/sites/default/files/CDS/EU_RD_Platform_CDS_Final.pdf).
3 |
4 |
5 |
6 | 
7 |
8 |
9 |
10 | #### RDF representation:
11 |
12 | You can check an exemplar RDF-based representation for this Common data Element [here](../exemplar_rdf/Biobank.nt)
13 |
14 | #### CDE implementation:
15 |
16 | If you're interested in implmenting this model on data, you can information around data requirements at our [Github implementation repo](https://github.com/ejp-rd-vp/CDE-semantic-model-implementations/blob/master/CDE_version_2.0.0/CSV_docs/glossary.md#biobank):
17 |
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/docs/Birthdate.md:
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1 | This module describes the data elements in the CDE 'Personal information' group. It specifically covers the CDE elements 2.1.'Date of Birth'.
2 | These elements, defined by the JRC, can be found on the EU RD Platform at [this link](https://eu-rd-platform.jrc.ec.europa.eu/sites/default/files/CDS/EU_RD_Platform_CDS_Final.pdf).
3 |
4 |
5 |
6 |
7 | 
8 |
9 |
10 |
11 |
12 |
13 | #### RDF representation:
14 |
15 | You can check an exemplar RDF-based representation for this Common data Element [here](../exemplar_rdf/Birthdate.nt)
16 |
17 | #### CDE implementation:
18 |
19 | If you're interested in implmenting this model on data, you can information around data requirements at our [Github implementation repo](https://github.com/ejp-rd-vp/CDE-semantic-model-implementations/blob/master/CDE_version_2.0.0/CSV_docs/glossary.md#birthdate):
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/docs/Birthyear.md:
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1 | # Birthyear
2 |
3 |
4 | 
5 |
6 |
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/docs/Body_measurement.md:
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1 | # Body measurement
2 |
3 |
4 |
5 | 
6 |
7 |
8 |
9 | #### RDF representation:
10 |
11 | You can check an exemplar RDF-based representation for this Common data Element [here](../exemplar_rdf/Body_measurement.nt)
12 |
13 | #### CDE implementation:
14 |
15 | If you're interested in implmenting this model on data, you can information around data requirements at our [Github implementation repo](https://github.com/ejp-rd-vp/CDE-semantic-model-implementations/blob/master/CDE_version_2.0.0/CSV_docs/glossary.md#body-measurement):
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/docs/Clinical_trials.md:
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1 | # Clinical trials
2 |
3 |
4 | 
5 |
6 |
7 |
8 |
9 | #### CDE implementation:
10 |
11 | If you're interested in implmenting this model on data, you can information around data requirements at our [Github implementation repo](https://github.com/ejp-rd-vp/CDE-semantic-model-implementations/blob/master/CDE_version_2.0.0/CSV_docs/glossary.md#clinical-trials):
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/docs/Consent.md:
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1 | This module describes the data elements related to consent from the group 'Research'. It specifically covers the CDE elements 7.1.'Agreement to be contacted for research purposes' and 7.2.'Consent to the reuse of data'.
2 | These elements, defined by the JRC, can be found on the EU RD Platform at [this link](https://eu-rd-platform.jrc.ec.europa.eu/sites/default/files/CDS/EU_RD_Platform_CDS_Final.pdf).
3 |
4 |
5 |
6 | 
7 |
8 |
9 |
10 |
11 | #### RDF representation:
12 |
13 | You can check an exemplar RDF-based representation for this Common data Element [here](../exemplar_rdf/Consent.nt)
14 |
15 | #### CDE implementation:
16 |
17 | If you're interested in implmenting this model on data, you can information around data requirements at our [Github implementation repo](https://github.com/ejp-rd-vp/CDE-semantic-model-implementations/blob/master/CDE_version_2.0.0/CSV_docs/glossary.md#consent-for-being-contacted):
18 |
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/docs/Deathdate.md:
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1 | This module describes the data elements in the module 'Patient's status'. It specifically covers the CDE elements 3.1.'Patient's status'.
2 | These elements, defined by the JRC, can be found on the EU RD Platform at [this link](https://eu-rd-platform.jrc.ec.europa.eu/sites/default/files/CDS/EU_RD_Platform_CDS_Final.pdf).
3 |
4 |
5 |
6 | 
7 |
8 |
9 |
10 |
11 | #### RDF representation:
12 |
13 | You can check an exemplar RDF-based representation for this Common data Element [here](../exemplar_rdf/Deathdate.nt)
14 |
15 | #### CDE implementation:
16 |
17 | If you're interested in implmenting this model on data, you can information around data requirements at our [Github implementation repo](https://github.com/ejp-rd-vp/CDE-semantic-model-implementations/blob/master/CDE_version_2.0.0/CSV_docs/glossary.md#deathdate):
--------------------------------------------------------------------------------
/docs/Diagnosis.md:
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1 | This module describes the data elements related to the diagnosis combining elements from the group 'Diagnosis'. It specifically covers the CDE elements 6.1.'Diagnosis of the rare disease'.
2 | These elements, defined by the JRC, can be found on the EU RD Platform at [this link](https://eu-rd-platform.jrc.ec.europa.eu/sites/default/files/CDS/EU_RD_Platform_CDS_Final.pdf)."
3 |
4 |
5 |
6 | 
7 |
8 |
9 |
10 | #### RDF representation:
11 |
12 | You can check an exemplar RDF-based representation for this Common data Element [here](../exemplar_rdf/Diagnosis.nt)
13 |
14 | #### CDE implementation:
15 |
16 | If you're interested in implmenting this model on data, you can information around data requirements at our [Github implementation repo](https://github.com/ejp-rd-vp/CDE-semantic-model-implementations/blob/master/CDE_version_2.0.0/CSV_docs/glossary.md#diagnosis):
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/docs/Disability.md:
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1 | This module describes the data element 8.1'Classification of functioning/disability' which is part of the group 'Disability'. These elements, defined by the JRC, can be found on the EU RD Platform at [this link](https://eu-rd-platform.jrc.ec.europa.eu/sites/default/files/CDS/EU_RD_Platform_CDS_Final.pdf).
2 |
3 |
4 |
5 |
6 | 
7 |
8 |
9 |
10 | #### RDF representation:
11 |
12 | You can check an exemplar RDF-based representation for this Common data Element [here](../exemplar_rdf/Disability.nt)
13 |
14 | #### CDE implementation:
15 |
16 | If you're interested in implmenting this model on data, you can information around data requirements at our [Github implementation repo](https://github.com/ejp-rd-vp/CDE-semantic-model-implementations/blob/master/CDE_version_2.0.0/CSV_docs/glossary.md#disability):
17 |
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/docs/First_visit.md:
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1 | This module describes the data elements related to the 'Care pathway'. It specifically covers the CDE element 4.1.'First contact with specialised centre'.
2 | These elements, defined by the JRC, can be found on the EU RD Platform at [this link](https://eu-rd-platform.jrc.ec.europa.eu/sites/default/files/CDS/EU_RD_Platform_CDS_Final.pdf).
3 |
4 |
5 |
6 | 
7 |
8 |
9 |
10 | #### RDF representation:
11 |
12 | You can check an exemplar RDF-based representation for this Common data Element [here](../exemplar_rdf/First_visit.nt)
13 |
14 | #### CDE implementation:
15 |
16 | If you're interested in implmenting this model on data, you can information around data requirements at our [Github implementation repo](https://github.com/ejp-rd-vp/CDE-semantic-model-implementations/blob/master/CDE_version_2.0.0/CSV_docs/glossary.md#first-confirmed-visit):
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/docs/Genotype.md:
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1 | This module describes the data element 6.2'Genetic Diagnosis' which is part of the group 'Diagnosis'.
2 | These elements, defined by the JRC, can be found on the EU RD Platform at [this link](https://eu-rd-platform.jrc.ec.europa.eu/sites/default/files/CDS/EU_RD_Platform_CDS_Final.pdf).
3 |
4 |
5 |
6 | 
7 |
8 |
9 |
10 |
11 | #### RDF representation:
12 |
13 | You can check an exemplar RDF-based representation for this Common data Element [here](../exemplar_rdf/Genotype.nt)
14 |
15 | #### CDE implementation:
16 | If you're interested in implmenting this model on data, you can information around data requirements at our [Github implementation repo](https://github.com/ejp-rd-vp/CDE-semantic-model-implementations/blob/master/CDE_version_2.0.0/CSV_docs/glossary.md#genetic-information):
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/docs/Imaging.md:
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1 | # Medical Imaging
2 |
3 |
4 | 
5 |
6 |
7 |
8 | #### RDF representation:
9 |
10 | You can check an exemplar RDF-based representation for this Common data Element [here](../exemplar_rdf/Imaging.nt)
11 |
12 | #### CDE implementation:
13 | If you're interested in implmenting this model on data, you can information around data requirements at our [Github implementation repo](https://github.com/ejp-rd-vp/CDE-semantic-model-implementations/blob/master/CDE_version_2.0.0/CSV_docs/glossary.md#imaging):
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/docs/Intervention.md:
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1 | # Clinical Treatment/Therapies
2 |
3 |
4 | 
5 |
6 |
7 |
8 | #### RDF representation:
9 |
10 | You can check an exemplar RDF-based representation for this Common data Element [here](../exemplar_rdf/Intervention.nt)
11 |
12 | #### CDE implementation:
13 | If you're interested in implmenting this model on data, you can information around data requirements at our [Github implementation repo](https://github.com/ejp-rd-vp/CDE-semantic-model-implementations/blob/master/CDE_version_2.0.0/CSV_docs/glossary.md#intervention-surgery):
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/docs/Laboratory.md:
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1 | # Laboratory measurement
2 |
3 |
4 |
5 | 
6 |
7 |
8 |
9 | #### RDF representation:
10 |
11 | You can check an exemplar RDF-based representation for this Common data Element [here](../exemplar_rdf/Lab_measurement.nt)
12 |
13 | #### CDE implementation:
14 |
15 | If you're interested in implmenting this model on data, you can information around data requirements at our [Github implementation repo](https://github.com/ejp-rd-vp/CDE-semantic-model-implementations/blob/master/CDE_version_2.0.0/CSV_docs/glossary.md#laboratory-measurement):
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/docs/Medication.md:
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1 | # Medications
2 |
3 |
4 |
5 | 
6 |
7 |
8 |
9 | #### RDF representation:
10 |
11 | You can check an exemplar RDF-based representation for this Common data Element [here](../exemplar_rdf/Medications.nt)
12 |
13 | #### CDE implementation:
14 |
15 | If you're interested in implmenting this model on data, you can information around data requirements at our [Github implementation repo](https://github.com/ejp-rd-vp/CDE-semantic-model-implementations/blob/master/CDE_version_2.0.0/CSV_docs/glossary.md#medications-and-therapies):
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/docs/Sex.md:
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1 | This module describes the data elements in the CDE 'Personal information' group. It specifically covers the CDE elements 2.2.'Sex'.
2 | These elements, defined by the JRC, can be found on the EU RD Platform at [this link](https://eu-rd-platform.jrc.ec.europa.eu/sites/default/files/CDS/EU_RD_Platform_CDS_Final.pdf).
3 |
4 |
5 |
6 | 
7 |
8 |
9 |
10 |
11 | #### RDF representation:
12 |
13 | You can check an exemplar RDF-based representation for this Common data Element [here](../exemplar_rdf/Sex.nt)
14 |
15 | #### CDE implementation:
16 |
17 | If you're interested in implmenting this model on data, you can information around data requirements at our [Github implementation repo](https://github.com/ejp-rd-vp/CDE-semantic-model-implementations/blob/master/CDE_version_2.0.0/CSV_docs/glossary.md#sex):
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/docs/Status.md:
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1 | This module describes the data elements in the module 'Patient's status'. It specifically covers the CDE elements 3.2.'Date of death'.
2 | These elements, defined by the JRC, can be found on the EU RD Platform at [this link](https://eu-rd-platform.jrc.ec.europa.eu/sites/default/files/CDS/EU_RD_Platform_CDS_Final.pdf).
3 |
4 |
5 |
6 |
7 | 
8 |
9 |
10 |
11 | #### RDF representation:
12 |
13 | You can check an exemplar RDF-based representation for this Common data Element [here](../exemplar_rdf/Status.nt)
14 |
15 | #### CDE implementation:
16 |
17 | If you're interested in implmenting this model on data, you can information around data requirements at our [Github implementation repo](https://github.com/ejp-rd-vp/CDE-semantic-model-implementations/blob/master/CDE_version_2.0.0/CSV_docs/glossary.md#status):
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/docs/Symptoms.md:
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1 | This module describes the data element 6.2 'Phenotype' in undiagnosed case which is part of the group 'Diagnosis'. These elements, defined by the JRC, can be found on the EU RD Platform at [this link](https://eu-rd-platform.jrc.ec.europa.eu/sites/default/files/CDS/EU_RD_Platform_CDS_Final.pdf).
2 |
3 |
4 |
5 | 
6 |
7 |
8 |
9 | #### RDF representation:
10 |
11 | You can check an exemplar RDF-based representation for this Common data Element [here](../exemplar_rdf/Symptoms.nt)
12 |
13 | #### CDE implementation:
14 |
15 | If you're interested in implmenting this model on data, you can information around data requirements at our [Github implementation repo](https://github.com/ejp-rd-vp/CDE-semantic-model-implementations/blob/master/CDE_version_2.0.0/CSV_docs/glossary.md#symptoms-or-signs):
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/docs/Symptoms_onset.md:
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1 | This module describes the data elements related to the diagnosis combining elements from the groups 'Disease history'. It specifically covers the CDE elements 5.1.'Age at onset'.
2 | These elements, defined by the JRC, can be found on the EU RD Platform at [this link](https://eu-rd-platform.jrc.ec.europa.eu/sites/default/files/CDS/EU_RD_Platform_CDS_Final.pdf).
3 |
4 |
5 |
6 | 
7 |
8 |
9 |
10 | #### RDF representation:
11 |
12 | You can check an exemplar RDF-based representation for this Common data Element [here](../exemplar_rdf/Symptoms_onset.nt)
13 |
14 | #### CDE implementation:
15 |
16 | If you're interested in implmenting this model on data, you can information around data requirements at our [Github implementation repo](https://github.com/ejp-rd-vp/CDE-semantic-model-implementations/blob/master/CDE_version_2.0.0/CSV_docs/glossary.md#symptoms-onset):
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/exemplar_rdf/Body_measurement.nt:
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1 | "Body_measurement agent"^^ .
2 | .
3 | "Body_measurement route"^^ .
4 | .
5 | "50012001"^^ .
6 | .
7 | "Identifier"^^ .
8 | .
9 | .
10 | .
11 | .
12 | .
13 | .
14 | "Body_measurement measurement process"^^ .
15 | .
16 | .
17 | .
18 | .
19 | "50012001"^^.
20 | .
21 | .
22 | .
23 | .
24 | "Patient role"^^ .
25 | "Body_measurement enddate: 2011-03-15"^^ .
26 | .
27 | "2011-03-15"^^ .
28 | .
29 | "20230618170934156313"^^.
30 | .
31 | 
8 |
9 | 
65 |
66 | 
8 |
9 | 
54 |
55 | 
8 |
9 | 
69 |
70 | 
8 |
9 | 
63 |
64 | 
8 |
9 | 
64 |
65 | 
8 |
9 | 
73 |
74 | 
11 |
12 | 
8 |
9 | 
83 |
84 | 
8 |
9 | 
68 |
69 | 
8 |
9 | 
73 |
74 | 
8 |
9 | 
63 |
64 | 
8 |
9 | 
38 |
39 | 
8 |
9 | 
85 |
86 |