├── styles ├── lens-reader.scss ├── lens-writer.scss ├── components │ ├── _bib-items-panel.scss │ ├── _add-bib-items-panel.scss │ ├── _bib-item.scss │ └── _cite-panel.scss ├── _lens.scss └── _wild_overrides.scss ├── app ├── assets │ ├── fonts │ │ ├── lato │ │ │ ├── lato-bold-latin.woff2 │ │ │ ├── lato-italic-latin.woff2 │ │ │ ├── lato-regular-latin.woff2 │ │ │ ├── lato-bold-latin-ext.woff2 │ │ │ ├── lato-italic-latin-ext.woff2 │ │ │ ├── lato-bold-italic-latin.woff2 │ │ │ ├── lato-regular-latin-ext.woff2 │ │ │ ├── lato-bold-italic-latin-ext.woff2 │ │ │ └── lato.scss │ │ └── font-awesome-4.4.0 │ │ │ ├── fonts │ │ │ ├── FontAwesome.otf │ │ │ ├── fontawesome-webfont.eot │ │ │ ├── fontawesome-webfont.ttf │ │ │ ├── fontawesome-webfont.woff │ │ │ └── fontawesome-webfont.woff2 │ │ │ ├── less │ │ │ ├── fixed-width.less │ │ │ ├── larger.less │ │ │ ├── list.less │ │ │ ├── core.less │ │ │ ├── font-awesome.less │ │ │ ├── stacked.less │ │ │ ├── bordered-pulled.less │ │ │ ├── rotated-flipped.less │ │ │ ├── path.less │ │ │ ├── animated.less │ │ │ └── mixins.less │ │ │ ├── scss │ │ │ ├── _fixed-width.scss │ │ │ ├── _larger.scss │ │ │ ├── _list.scss │ │ │ ├── font-awesome.scss │ │ │ ├── _core.scss │ │ │ ├── _stacked.scss │ │ │ ├── _bordered-pulled.scss │ │ │ ├── _rotated-flipped.scss │ │ │ ├── _path.scss │ │ │ ├── _animated.scss │ │ │ └── _mixins.scss │ │ │ └── HELP-US-OUT.txt │ └── index.html ├── app.scss ├── backend.js └── app.js ├── .jshintrc ├── lens.sublime-project ├── packages ├── bibliography │ ├── citeproc │ │ ├── csl_nodejs_jsdom.js │ │ ├── csl_jquery.js │ │ └── xmldom.js │ ├── BibItemCitationTool.js │ ├── BibItemCitationCommand.js │ ├── BibItemCitation.js │ ├── BibItemXMLConverter.js │ ├── BibItemCitationXMLConverter.js │ ├── BibItem.js │ ├── BibItemComponent.js │ ├── BibliographySummary.js │ ├── BibItemEntry.js │ ├── BibliographyComponent.js │ ├── CrossrefSearch.js │ ├── BibItemsPanel.js │ ├── Bibliography.js │ ├── AddBibItemsPanel.js │ ├── CiteprocCompiler.js │ └── CiteprocDefaultConfig.js ├── metadata │ ├── Author.js │ ├── ArticleMeta.js │ └── MetadataXMLConverter.js ├── figures │ ├── ImageFigure.js │ ├── ImageFigureCitationTool.js │ ├── ImageFigureCitationCommand.js │ ├── ImageFigureCitation.js │ ├── ImageFigureCitationXMLConverter.js │ ├── ImageFigureXMLConverter.js │ ├── ImageFigureEntry.js │ └── ManageCollectionComponent.js ├── citations │ ├── CitationXMLConverter.js │ ├── Citation.js │ ├── citation.scss │ ├── CitationComponent.js │ ├── CitationCommand.js │ └── CitePanel.js ├── reader │ └── Cover.js └── writer │ ├── CoverEditor.js │ └── WriterTools.js ├── model ├── defaultLensArticle.js ├── LensArticleExporter.js ├── LensArticleImporter.js ├── articleSchema.js ├── LensArticle.js └── Collection.js ├── .gitignore ├── package.json ├── i18n ├── de.js └── en.js ├── LICENSE ├── server.js ├── gulpfile.js ├── legacy ├── export_tool.js ├── cite_tool.js ├── insert_table_tool.js └── insert_figure_tool.js ├── README.md ├── LensController.js ├── LensReader.js ├── LensWriter.js └── data └── small-example.xml /styles/lens-reader.scss: -------------------------------------------------------------------------------- 1 | @import '_lens'; 2 | 3 | .sc-lens-reader { 4 | @extend %lens; 5 | } 6 | -------------------------------------------------------------------------------- /styles/lens-writer.scss: -------------------------------------------------------------------------------- 1 | @import '_lens'; 2 | 3 | .sc-lens-writer { 4 | @extend %lens; 5 | } 6 | -------------------------------------------------------------------------------- /app/assets/fonts/lato/lato-bold-latin.woff2: -------------------------------------------------------------------------------- https://raw.githubusercontent.com/substance/lens/HEAD/app/assets/fonts/lato/lato-bold-latin.woff2 -------------------------------------------------------------------------------- /app/assets/fonts/lato/lato-italic-latin.woff2: -------------------------------------------------------------------------------- https://raw.githubusercontent.com/substance/lens/HEAD/app/assets/fonts/lato/lato-italic-latin.woff2 -------------------------------------------------------------------------------- /app/assets/fonts/lato/lato-regular-latin.woff2: -------------------------------------------------------------------------------- https://raw.githubusercontent.com/substance/lens/HEAD/app/assets/fonts/lato/lato-regular-latin.woff2 -------------------------------------------------------------------------------- /styles/components/_bib-items-panel.scss: -------------------------------------------------------------------------------- 1 | .sc-bib-items-panel { 2 | .se-bibliography-summary { 3 | padding: $default-padding; 4 | } 5 | } -------------------------------------------------------------------------------- /app/assets/fonts/lato/lato-bold-latin-ext.woff2: -------------------------------------------------------------------------------- https://raw.githubusercontent.com/substance/lens/HEAD/app/assets/fonts/lato/lato-bold-latin-ext.woff2 -------------------------------------------------------------------------------- /app/assets/fonts/lato/lato-italic-latin-ext.woff2: -------------------------------------------------------------------------------- https://raw.githubusercontent.com/substance/lens/HEAD/app/assets/fonts/lato/lato-italic-latin-ext.woff2 -------------------------------------------------------------------------------- /app/assets/fonts/lato/lato-bold-italic-latin.woff2: -------------------------------------------------------------------------------- https://raw.githubusercontent.com/substance/lens/HEAD/app/assets/fonts/lato/lato-bold-italic-latin.woff2 -------------------------------------------------------------------------------- /app/assets/fonts/lato/lato-regular-latin-ext.woff2: -------------------------------------------------------------------------------- https://raw.githubusercontent.com/substance/lens/HEAD/app/assets/fonts/lato/lato-regular-latin-ext.woff2 -------------------------------------------------------------------------------- /app/assets/fonts/lato/lato-bold-italic-latin-ext.woff2: -------------------------------------------------------------------------------- https://raw.githubusercontent.com/substance/lens/HEAD/app/assets/fonts/lato/lato-bold-italic-latin-ext.woff2 -------------------------------------------------------------------------------- /app/assets/fonts/font-awesome-4.4.0/fonts/FontAwesome.otf: -------------------------------------------------------------------------------- https://raw.githubusercontent.com/substance/lens/HEAD/app/assets/fonts/font-awesome-4.4.0/fonts/FontAwesome.otf -------------------------------------------------------------------------------- /app/assets/fonts/font-awesome-4.4.0/fonts/fontawesome-webfont.eot: -------------------------------------------------------------------------------- https://raw.githubusercontent.com/substance/lens/HEAD/app/assets/fonts/font-awesome-4.4.0/fonts/fontawesome-webfont.eot -------------------------------------------------------------------------------- /app/assets/fonts/font-awesome-4.4.0/fonts/fontawesome-webfont.ttf: -------------------------------------------------------------------------------- https://raw.githubusercontent.com/substance/lens/HEAD/app/assets/fonts/font-awesome-4.4.0/fonts/fontawesome-webfont.ttf -------------------------------------------------------------------------------- /app/assets/fonts/font-awesome-4.4.0/fonts/fontawesome-webfont.woff: -------------------------------------------------------------------------------- https://raw.githubusercontent.com/substance/lens/HEAD/app/assets/fonts/font-awesome-4.4.0/fonts/fontawesome-webfont.woff -------------------------------------------------------------------------------- /app/assets/fonts/font-awesome-4.4.0/fonts/fontawesome-webfont.woff2: -------------------------------------------------------------------------------- https://raw.githubusercontent.com/substance/lens/HEAD/app/assets/fonts/font-awesome-4.4.0/fonts/fontawesome-webfont.woff2 -------------------------------------------------------------------------------- /styles/components/_add-bib-items-panel.scss: -------------------------------------------------------------------------------- 1 | .sc-add-bib-items-panel { 2 | .sc-scroll-pane { 3 | top: 40px; 4 | } 5 | 6 | .se-search-form { 7 | padding: 20px; 8 | } 9 | } -------------------------------------------------------------------------------- /app/assets/fonts/font-awesome-4.4.0/less/fixed-width.less: -------------------------------------------------------------------------------- 1 | // Fixed Width Icons 2 | // ------------------------- 3 | .@{fa-css-prefix}-fw { 4 | width: (18em / 14); 5 | text-align: center; 6 | } 7 | -------------------------------------------------------------------------------- /app/assets/fonts/font-awesome-4.4.0/scss/_fixed-width.scss: -------------------------------------------------------------------------------- 1 | // Fixed Width Icons 2 | // ------------------------- 3 | .#{$fa-css-prefix}-fw { 4 | width: (18em / 14); 5 | text-align: center; 6 | } 7 | -------------------------------------------------------------------------------- /.jshintrc: -------------------------------------------------------------------------------- 1 | { 2 | "esnext": true, 3 | "node": true, 4 | "devel": true, 5 | "latedef": true, 6 | "undef": true, 7 | "unused": true, 8 | "sub": true, 9 | "predef": [ 10 | "localStorage", 11 | "window", 12 | "document", 13 | "i18n" 14 | ] 15 | } -------------------------------------------------------------------------------- /lens.sublime-project: -------------------------------------------------------------------------------- 1 | { 2 | "folders": 3 | [ 4 | { 5 | "path": "./", 6 | "folder_exclude_patterns": ["node_modules"] 7 | }, 8 | { 9 | "path": "./node_modules/substance", 10 | "folder_exclude_patterns": ["node_modules"] 11 | } 12 | ] 13 | } 14 | -------------------------------------------------------------------------------- /packages/bibliography/citeproc/csl_nodejs_jsdom.js: -------------------------------------------------------------------------------- 1 | // just a shim which imports our jquery based xml adapter. 2 | 3 | var XmlAdapter; 4 | if (typeof window === 'undefined') { 5 | XmlAdapter = require('./csl_jquery'); 6 | } else { 7 | XmlAdapter = require('./xmldom'); 8 | } 9 | 10 | module.exports = { 11 | CSL_NODEJS_JSDOM: XmlAdapter 12 | }; 13 | -------------------------------------------------------------------------------- /packages/metadata/Author.js: -------------------------------------------------------------------------------- 1 | 'use strict'; 2 | 3 | var DocumentNode = require('substance/model/DocumentNode'); 4 | 5 | function Author() { 6 | Author.super.apply(this, arguments); 7 | } 8 | 9 | DocumentNode.extend(Author); 10 | 11 | Author.static.name = "author"; 12 | 13 | Author.static.defineSchema({ 14 | "name": "string" 15 | }); 16 | 17 | module.exports = Author; 18 | -------------------------------------------------------------------------------- /app/assets/fonts/font-awesome-4.4.0/HELP-US-OUT.txt: -------------------------------------------------------------------------------- 1 | I hope you love Font Awesome. If you've found it useful, please do me a favor and check out my latest project, 2 | Fonticons (https://fonticons.com). It makes it easy to put the perfect icons on your website. Choose from our awesome, 3 | comprehensive icon sets or copy and paste your own. 4 | 5 | Please. Check it out. 6 | 7 | -Dave Gandy 8 | -------------------------------------------------------------------------------- /app/assets/index.html: -------------------------------------------------------------------------------- 1 | 2 | 3 |
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Enter your article here.
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Content from: http://lens.elifesciences.org/00005
56 |Polycomb Repressive Complex 2 (PRC2) is essential for gene silencing, establishing transcriptional repression of specific genes by tri-methylating Lysine 27 of histone H3, a process mediated by cofactors such as AEBP2. In spite of its biological importance, little is known about PRC2 architecture and subunit organization. Here, we present the first three-dimensional electron microscopy structure of the human PRC2 complex bound to its cofactor AEBP2. Using a novel internal protein tagging-method, in combination with isotopic chemical cross-linking and mass spectrometry, we have localized all the PRC2 subunits and their functional domains and generated a detailed map of interactions. The position and stabilization effect of AEBP2 suggests an allosteric role of this cofactor in regulating gene silencing. Regions in PRC2 that interact with modified histone tails are localized near the methyltransferase site, suggesting a molecular mechanism for the chromatin-based regulation of PRC2 activity.
58 | 59 |Some annotated content (see Doe, 2010 and Figure 1 and Table 1).
63 | 64 |In preliminary experiments, we reconstituted the tetrameric PRC2 complex (Ezh2/EED/Suz12/RbAp48) in an insect cell expression system, following previous protocols established to reconstitute a functional PRC2 complex (Pasini et al., 2004; Ketel et al., 2005; Margueron et al., 2008). When analyzed by SDS page the purified complex appeared to be stoichiometric and biochemically homogeneous (data not shown). However, further analysis to generate reference-free 2D class averages and a 3D reconstruction were limited in resolution and lacked clear structural details (data not shown), indicating the presence of extreme conformational flexibility and hampering further structural studies of this tetrameric PRC2.
66 | 67 | 68 |Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet.
72 | 73 | 74 |End of file
77 | 78 | 79 | -------------------------------------------------------------------------------- /packages/bibliography/CiteprocDefaultConfig.js: -------------------------------------------------------------------------------- 1 | 'use strict'; 2 | 3 | function CiteprocDefaultConfig(options) { 4 | options = options || {}; 5 | this.style = options.style || CiteprocDefaultConfig.defaultStyle; 6 | this.locale = options.locale || CiteprocDefaultConfig.defaultLocale; 7 | } 8 | 9 | CiteprocDefaultConfig.defaultStyleName = 'PLOS'; 10 | CiteprocDefaultConfig.defaultStyle = ''; 11 | CiteprocDefaultConfig.defaultLocale = {"en-US":"